Protein Modification Reagents
Medchemexpress LLC DBCO-PEG2-DBCO | 2639395-48-3 | MFCD34178807 | 95.4% | 722.83 g/mol | C44H42N4O6 | 10 MG
DBCO-PEG2-DBCO is a bifunctional polyethylene glycol (PEG) linker bearing two terminal dibenzocyclooctyne (DBCO) groups. It is designed for copper-free strain-promoted alkyne-azide cycloaddition (SPAAC) to enable bioconjugation without copper catalysts. The short PEG2 spacer increases solubility and flexibility, and the product is supplied with solubility and storage guidance for research use.
- Supports copper-free click chemistry (SPAAC)
- Contains two terminal DBCO reactive groups
- PEG2 spacer improves aqueous solubility and flexibility
- High reported purity suitable for research applications
- Soluble in DMSO; in vitro and in vivo formulation protocols provided
- Recommended storage as powder at -20°C for long-term stability
Abcam Kinase Assay Buffer I, 1ML
Stock solution of buffer used for assaying kinase protein.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Methyltetrazine-PEG5-NHS ester | 1802907-92-1 | 97.0% | C24H31N5O9 | 100 MG
Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are molecules composed of two distinct ligands connected by a linker. These molecules harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used as a PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Selectively degrades target proteins via the ubiquitin-proteasome system
Medchemexpress LLC Cy5-PEG5-azide bromide | 98.8% | C44H63BrN6O6 | 2 MG
Cy5-PEG5-azide is a PEG-based linker utilized in the synthesis of PROTACs, which are compounds designed to selectively degrade target proteins. This reagent facilitates click chemistry reactions, containing an azide group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, or strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
- Enables targeted protein degradation.
- Supports efficient synthesis of degraders.
- Compatible with multiple click chemistry methods.
- Offers a versatile conjugation tool for research.
- High purity for reliable experimental results.
Medchemexpress LLC DBCO-PEG4-DBCO | 2182601-68-7 | 97.4% | 810.93 | C48H50N4O8 | 10 MG
DBCO-PEG4-DBCO is a PEG-based bifunctional linker bearing two dibenzocyclooctyne (DBCO) groups. It is used as a click chemistry reagent for strain-promoted alkyne-azide cycloaddition (SPAAC) and as a PEG linker in PROTAC and antibody-drug conjugate (ADC) synthesis.
- Click chemistry reagent enabling SPAAC with azide-functionalized partners.
- Provides a PEG4 spacer to improve solubility and linker flexibility.
- High solubility in DMSO; manufacturer provides in vitro and in vivo formulation protocols.
- Typical purity around 97.4% and appears as a white to yellow solid.
- Suitable for use in PROTAC and ADC synthesis workflows.
Medchemexpress LLC Amino-PEG6-amido-bis-PEG5-N3 | 1147.31 | C48H94N10O21 | 5 MG
Amino-PEG6-amido-bis-PEG5-N3 is a cleavable 11-unit polyethylene glycol (PEG) linker bearing amino and azide functional groups, designed for use in antibody-drug conjugate synthesis and bioconjugation via click chemistry.
- Cleavable 11-unit PEG linker useful for ADC construction.
- Contains an azide group for copper-catalyzed and strain-promoted click reactions.
- Amino terminus enables conjugation or further functionalization.
- Improves solubility and flexibility between linked molecules.
- Available in small research quantities for conjugation workflows.
Medchemexpress LLC Endo-BCN-PEG4-PFP ester | 2904607-26-5 | 95.0% | 607.56 | 25 MG
endo-BCN-PEG4-PFP ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It acts as a click chemistry reagent, featuring a BCN group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This mechanism supports the development of PROTACs, which degrade target proteins via the ubiquitin-proteasome system. This product is for research use only.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains a BCN group for SPAAC with azide groups
- Used in PROTAC synthesis
- Enables selective degradation of target proteins
- Functions through the intracellular ubiquitin-proteasome system
- Intended for research use only
Mitegen PEG 5000 MME, 50%(w/v), 250 ml, CAS# 9004-74-4
Use our stock solutions directly or as a component in solutions you create in your own lab. We prepare our stock solutions using high quality raw materials, ASTM Type 1 water, and sterile packaging. Our stock solutions are intended for Research and Development Use Only.
Medchemexpress LLC Bis-PEG4-NHS ester | 1g
Bis- PEG4- NHS ester is a nonclaevable 4-unit PEG linker for antibody-agent-conjugation (ADC)
Medchemexpress LLC M-PEG12-DBCO | 96.9% | C44H66N2O14 | 50 MG
m-PEG12-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. This product is for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Enables selective degradation of target proteins
Medchemexpress LLC 4,7,10,13-tetraoxapentadecanoic acid, 15-hydroxy-, 1,1-dimethylethyl ester | 518044-32-1 | 99.3% | 322.39 g/mol | C15H30O7 | 25 G
Hydroxy-PEG4-(CH2)2-Boc is a hydroxy-terminated PEG4 spacer with a Boc-protected terminal group used as a linker in bioconjugation chemistry. It is commonly employed for antibody-drug conjugate and PROTAC synthesis, and is provided at high purity for research use only.
- Hydroxy-terminated PEG4 spacer with Boc-protected terminal
- Uncleavable linker suitable for antibody-drug conjugate synthesis
- Applicable as a PROTAC linker in targeted protein degradation workflows
- High purity (99.3% by GC) with characterized molecular weight 322.39 g/mol
- Available in multiple pack sizes, including 25 g
- For research use only; not validated for medical applications
Medchemexpress LLC 3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy- | 70678-95-4 | ≥97.0% | C10H20O7 | 250 MG
Hydroxy-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins